653-47 |
| カタログ番号GC62279 |
増強剤である 653-47 は、666-15 の cAMP 応答エレメント結合タンパク質 (CREB) 阻害活性を大幅に増強します。 653-47 も非常に弱い CREB 阻害剤であり、IC50 は 26.3 μM です。
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Cas No.: 1224678-75-4
Sample solution is provided at 25 µL, 10mM.
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653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].
653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15[1].
[1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.
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