8-Nitroguanine |
| カタログ番号GC18426 |
8-ニトログアニンは、反応性窒素種（RNS）によるDNA中のグアニン塩基の酸化的損傷によって炎症時およびin vitroでペルオキシニトリットおよび他のRNS試薬とDNAが反応することによって形成される硝酸化グアニン誘導体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 168701-80-2
Sample solution is provided at 25 µL, 10mM.
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8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents. It is mutagenic and induces G:C to T:A transversion in DNA. Incorporation of 8-nitroguanine as an 8-nitroG:anti-G base pair into a primer template stalls human DNA polymerase β and induces a 2:1 preference for deoxyadenosine (dA) insertion over deoxycytosine (dC). 8-Nitroguanine levels are increased in the lung tissue of mice with conditional expression of mutant K-Ras(G12V) that developed lung adenocarcinoma and in the lung tissue and peripheral lymphocyte DNA of cigarette smoke-exposed rats. It is also increased in the lung tissue of influenza- or Sendai virus-infected mice and the colon epithelial cells of mice in an inflammatory bowel disease (IBD) model.
Review for 8-Nitroguanine
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
Review for 8-Nitroguanine
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