9-Decyn-1-ol |
| カタログ番号GC66222 |
9-デシン-1-オールは、PROTAC の合成に使用できるアルキル/エーテルベースの PROTAC リンカーです。 9-デシン-1-オールを使用して、GDC-0068 をレナリドマイドと結合させ、INY-03-041 を生成できます。 INY-03-041 は、強力で選択性の高い、PROTAC ベースの汎 Akt 分解剤です。 INY-03-041 は、Akt1、Akt2、および Akt3 をそれぞれ 2.0 nM、6.8 nM、および 3.5 nM の IC50 で阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 17643-36-6
Sample solution is provided at 25 µL, 10mM.
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9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1].
9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker[1].
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