ACH-000143 |
| カタログ番号GC62825 |
ACH-000143 は強力な経口活性メラトニン受容体アゴニストで、MT1 と MT2 の EC50 値はそれぞれ 0.06 nM と 0.32 nM です 。
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Cas No.: 2225836-30-4
Sample solution is provided at 25 µL, 10mM.
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ACH-000143 is a potent and orally active melatonin receptor agonist, with EC50 values of 0.06 nM and 0.32 nM for MT1 and MT2, respectively[1].
ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats[1].ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate[1].ACH-000143 significantly reduces plasma glucose at 10 mg/kg (-16.4%, p < 0.05) and 30 mg/kg (-16.9%, p < 0.01)[1].
[1]. Marcos Antonio Ferreira Jr, et al. Discovery of ACH-000143: A Novel Potent and Peripherally Preferred Melatonin Receptor Agonist that Reduces Liver Triglycerides and Steatosis in Diet-Induced Obese Rats. J Med Chem. 2021 Feb 25;64(4):1904-1929.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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