AGN 192836 |
| カタログ番号GC32599 |
AGN 192836 は、α2A、α2B、および α2C 受容体に対してそれぞれ 8.7、41、および 6.6 nM の EC50 を持つ、強力かつ選択的な α2 アドレナリン作動性アゴニストです。
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Cas No.: 171102-29-7
Sample solution is provided at 25 µL, 10mM.
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AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.
Binding assays demonstrates that AGN 192836 is 1200-fold selective for the α2A-receptor relative to the α1-receptor, 50-fold selective for the α2A-receptor relative to the α2B-receptor, and 10-fold selective for the α2Areceptor relative to the α2C-receptor[1].
AGN 192836 is equally efficacious when compared to brimonidine for the reduction of intraocular pressure upon topical administration to the rabbit and more efficacious than brimonidine for the reduction of blood pressure upon intravenous administration to monkey[1].
[1]. Stephen M, et al. Synthesis and Evaluation of 2-(Arylamino)imidazoles as α2-Adrenergic Agonists. J. Med. Chem., 1997, 40 (1), pp 18-23
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