AL 6598 |
| カタログ番号GC42760 |
眼圧の上昇は、緑内障を発症する重要なリスクファクターです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 170291-06-2
Sample solution is provided at 25 µL, 10mM.
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Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2α and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 µM and demonstrates an EC50 value of 0.80 µM in an in vitro functional assay. Designed to enhance corneal absorption, AL 6598 produces a maximum 53% drop in IOP of the ocular hypertensive monkey with a 1 µg dose given twice daily.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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