Biliverdin (hydrochloride) |
| カタログ番号GC42932 |
ビリベルジン（塩酸塩）は、ヘムの分解によって形成されるテトラピロールの水溶性化合物です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 856699-18-8
Sample solution is provided at 25 µL, 10mM.
Biliverdin is a green bile pigment produced from the oxidation of heme in a reaction catalyzed by heme oxygenase and is further reduced to bilirubin by biliverdin reductase.[1][2] Biliverdin regulates the cellular heme degradation process by inhibiting substrates from binding to the catalytic site of heme oxygenase. Bile pigments such as biliverdin are known to possess anti-mutagenic and antioxidant properties.[3][4]
Reference:
[1]. Liu, Y., Moënne-Loccoz, P., Loehr, T.M., et al. Heme oxygenase-1, intermediates in verdoheme formation and the requirement for reduction equivalents. The Journal of Biological Chemisty 272, 6909-6917 (1997).
[2]. Maines, M.D. The heme oxygenase system: A regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 37, 517-554 (1997).
[3]. Bulmer, A.C., Ried, K., Blanchfield, J.T., et al. The anti-mutagenic properties of bile pigments. Mutation Research 658(1-2), 28-41 (2008).
[4]. Mölzer, C., Huber, H., Steyrer, A., et al. In vitro antioxidant capacity and antigenotoxic properties of protoporphyrin and structurally related tetrapyrroles. Free Rad.Res. 46(11), 1369-1377 (2012).
| Cas No. | 856699-18-8 | SDF | |
| Chemical Name | 3,18-diethenyl-1,19,22,24-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid, monohydrochloride | ||
| Canonical SMILES | OC(CCC1=C(/C=C2C(CCC(O)=O)=C(C)C(/C=C3NC(C(C=C)=C\3C)=O)=N/2)NC(/C=C4NC(C(C)=C\4C=C)=O)=C1C)=O.Cl | ||
| Formula | C33H34N4O6•HCl | M.Wt | 619.1 |
| 溶解度 | 20mg/mL in DMSO, 20mg/mL in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.6152 mL | 8.0762 mL | 16.1525 mL |
| 5 mM | 0.323 mL | 1.6152 mL | 3.2305 mL |
| 10 mM | 0.1615 mL | 0.8076 mL | 1.6152 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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