BMS-1001 |
| カタログ番号GC25160 |
BMS-1001は、PD-1/PD-L1相互作用の強力な阻害剤であり、EC50値は253 nMです。BMS-1001は、可溶性PD-L1の抑制効果を軽減し、T細胞受容体介在性活性化によるTリンパ球の活性化を促進します。
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Cas No.: 2113650-03-4
Sample solution is provided at 25 µL, 10mM.
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BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.
BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. BMS-1001 is effective in attenuating the inhibitory effect of the cell surface-associated PD-L1.[1]
[1] Lukasz Skalniak, et al. Oncotarget. 2017 Aug 7;8(42):72167-72181.
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