BPC 157 (acetate) (Synonyms: GEPPPGKPADDAGLV, Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val)

Body protection compound 157 (BPC 157) is a pentadecapeptide fragment of BPC that has been found in gastric juice and has diverse biological activities.¹ It increases cell migration of, and F-actin formation in, primary rat tendon fibroblasts when used at a concentration of 2 µg/ml.² BPC 157 (0.01 and 10 µg/kg, i.p.) reduces paw swelling, bone erosion, and inflamed joint mononuclear cell infiltration in a rat model of rheumatoid arthritis induced by complete Freund's adjuvant (CFA).³ It decreases the lesion size of gastric ulcers induced by indomethacin , aspirin , or diclofenac in rats at the same doses. BCP 157 (0.01 and 10 µg/kg, i.p.) decreases the duration of catalepsy and reduces tremor severity in a mouse model of Parkinson's disease induced by MPTP.⁴

1.Sikiric, P., Seiwerth, S., Rucman, R., et al.Brain-gut axis and pentadecapeptide BPC 157: Theoretical and practical implicationsCurr. Neuropharmacol.14(8)857-865(2016) 2.Chang, C.-H., Tsai, W.-C., Lin, M.-S., et al.The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migrationJ. Appl. Physiol.110(3)774-780(2011) 3.Sikiric, P., Seiwerth, S., Grabarevic, Z., et al.Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in ratsJ. Physiol. (Paris)91(3-5)113-122(1997) 4.Sikiric, P., Marovic, A., Matoz, W., et al.A behavioural study of the effect of pentadecapeptide BPC 157 in Parkinson's disease models in mice and gastric lesions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineJ. Physiol. (Paris)93(6)505-512(1999)