Brimonidine-d4 |
| カタログ番号GC40077 |
ブリモニジン-d4は、GC-またはLC-MSによるブリモニジンの定量のための内部標準として使用することを目的としています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1184971-51-4
Sample solution is provided at 25 µL, 10mM.
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Brimonidine-d4 is intended for use as an internal standard for the quantification of brimonidine by GC- or LC-MS. Brimonidine is an agonist of α2-adrenergic receptors (α2-ARs; Kis = 2.7, 52, and 44 nM for α2A, α2B, and α2C-ARs, respectively, in CHO cells). It is selective for α2-ARs over α1-ARs (Ki = 1,800 nM in human brain). Brimonidine lowers intraocular pressure in DBA/2J mice, a model of glaucoma, to control levels when applied topically to the eye as a 0.1% solution. It also inhibits glutamate release, prevents upregulation of NMDA receptors containing NR1 and NR2A subunits, and protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia when administered at a dose of 1 mg/kg per day. Formulations containing brimonidine have been used in the treatment of open-angle glaucoma and ocular hypertension.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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