UNC2541 |
| カタログ番号GC37858 |
UNC2541 は強力な Mer チロシンキナーゼ (MerTK) 特異的阻害剤であり、MerTK ATP ポケットに結合し、IC50 は 4.4 nM で、Axl、Tyro3、および Flt3 よりも選択的です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1612782-86-1
Sample solution is provided at 25 µL, 10mM.
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UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1]. UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl (IC50, 120 nM), Tyro3 (IC50, 220 nM) and Flt3 (IC50, 320 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].
[1]. McIver AL, et al. Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem. 2017 Feb 3;12(3):207-213.
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