BRL44385 |
| カタログ番号GC32371 |
BRL44385 は、単純ヘルペス ウイルス 1 型および 2 型 (HSV-1 および HSV2)、水痘帯状疱疹ウイルス (VZV)、エプスタイン-バーウイルス (EBV) の複製を強力かつ選択的に阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 114778-60-8
Sample solution is provided at 25 µL, 10mM.
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BRL44385 is a potent and selective inhibitor of the replication of herpes simplex virus types 1 and 2 (HSV-1 and HSV2), varicella zoster virus (VZV) and Epstein-Barr virus (EBV).
BRL44385 is a selective antiherpesvirus agent. Following oral administration, BRL 55792 is very well absorbed and provides high and prolonged concentrations of BRL44385 in the blood. In mice 15 min and 60 min after administration of a single oral dose of BRL 55792, the concentrations of BRL44385 in the blood are considerably higher than those obtain after oral administration of either BRL44385 or BRL46720 and the bioavailability of BRL 44385 from oral BRL 55792 is 66% of that achieves with the same dose of the sodium salt of BRL44385 administered intravenously[1].
[1]. M. R. Harnden, et al. Synthesis, oral bioavailability and in vivo activity of acetal derivatives of the selective antiherpesvirus agent 9-(3-hydroxypropoxy) guanine (SRL 44385). Antiviral Chemistry & Chemotherapy (1994) 5(3), 147-154.
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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