Busulfan-d8 (Synonyms: Busulphan-d8, Mielosan-d8, Milecitan-d8, Myeloleukon-d8, Mylecytan-d8, Myleran-d8) |
| カタログ番号GC46962 |
Busulfan-D8 は、Busulfan と標識された重水素です。ブスルファンは、アルキル化抗腫瘍剤として作用するアルキルスルホン酸塩です。ブスルファンは、DNA の鎖内および鎖間架橋の両方を形成します。哺乳動物では、ブスルファンは、リンパ球レベルや体液性抗体反応に大きな影響を与えることなく、造血前駆細胞の生成を大幅かつ長期にわたって減少させます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 116653-28-2
Sample solution is provided at 25 µL, 10mM.
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Busulfan-d8 is intended for use as an internal standard for the quantification of busulfan by GC- or LC-MS. Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent.1 It forms both intra- and interstrand crosslinks on DNA.2,3 In mammals, busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.4
1.Appelbaum, F.R.Optimizing the conditioning regimen for acute myeloid leukemiaBest Pract.Res.Clin.Haematol.22(4)543-550(2009) 2.Iwamoto, T., Hiraku, Y., Oikawa, S., et al.DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effectCancer Science95454-458(2004) 3.Ponti, M., Souhami, R.L., Fox, B.W., et al.DNA interstrand crosslinking and sequence selectivity of dimethanesulphonatesBritish Journal of Cancer63(5)743-747(1991) 4.Copelan, E.A., and Deeg, H.J.Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiationBlood80(7)1648-1658(1992)
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