Carbazomycin C |
| カタログ番号GC48850 |
多様な生物学的活性を持つ細菌代謝産物
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 108073-62-7
Sample solution is provided at 25 µL, 10mM.
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Carbazomycin C is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2,3 It is active against S. aureus, B. anthracis, B. subtilis, and M. flavus (MICs = 50, 25, 100, and 50 µg/ml, respectively), the fungi T. asteroides and T. mentagrophytes (MICs = 25 and 100 µg/ml, respectively), and P. falciparum (IC50 = 2.1 µg/ml).2 It is also active against a panel of five plant pathogenic fungi (MICs = 12.5-100 µg/ml).1 Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells (IC50s = 9.8, 21.4, and 8.2 µg/ml, respectively).2 It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts (IC50 = 1.9 µM).3
1.Naid, T., Kitahara, T., Kaneda, M., et al.Carbazomycins C, D, E and F, minor components of the carbazomycin complexJ. Antibiot. (Tokyo)40(2)157-164(1987) 2.Intaraudom, C., Rachtawee, P., Suvannakad, R., et al.Antimalarial and antituberculosis substances from Streptomyces sp. BCC26924Tetrahedron67(39)7593-7597(2011) 3.Hook, D.J., Yacobucci, J.J., O'Connor, S., et al.Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compoundsJ. Antibiot. (Tokyo)43(10)1347-1348(1990)
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