PI3Kγ inhibitor 1 |
| カタログ番号GC36910 |
PI3Kγ阻害剤１は、特許ＷＯ２０１４００４４７０Ａ１から抽出されたＰＩ３ＫδおよびＰＩ３Ｋγ阻害剤であり、表４の化合物１６８は、<１００ｎＭのＩＣ５０を有する。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1172118-03-4
Sample solution is provided at 25 µL, 10mM.
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PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC50s of <100 nM. PI3Kδ|100 nM (IC50)|PI3Kγ|100 nM (IC50)|PI3Kα|10 μM (IC50)|PI3Kβ|10 μM (IC50)
In Table 3, PI3Kγ inhibitor 1 (Compound 168) inhibits PI3Kδ, PI3Kγ, PI3Kα and PI3Kβ with IC50s of <100 nM, <100 nM, <10 μM and <10 μM, respectively. PI3Kγ inhibitor 1 inhibits B cell proliferation with an EC50<100 nM.
[1]. Vito J. Palombella, et al. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using pi3 kinase inhibitors. WO 2014004470 A1.
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