Phensuximide (Synonyms: (±)-Phensuximide) |
| カタログ番号GC45547 |
フェンスクシミドは、経口で活性なスクシンイミド抗てんかん薬および抗痙攣薬です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 86-34-0
Sample solution is provided at 25 µL, 10mM.
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Phensuximide is an anticonvulsant.1 It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole in mice (ED50s = 112 and 50 mg/kg, respectively). Phensuximide (1.25 mmol/kg, i.p.) induces proteinuria and hematuria in rats.2 Formulations containing phensuximide have been used in the treatment of petit mal seizures.
References
1. Kornet, M.J., Crider, A.M., and Magarian, E.O. Potential long-acting anticonvulsants. 1. Synthesis and activity of succinimides containing an alkylating group at the 2 position. J. Med. Chem. 20(3), 405-409 (1977).
2. Rankin, G.O., Cressey-Veneziano, K., Wang, R.T., et al. Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat. J. Appl. Toxicol. 6(5), 349-356 (1986).
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