ICA-27243 |
| カタログ番号GC39293 |
ICA-27243 は、0.38 μM の EC50 を持つ、選択的で強力な経口活性 KCNQ2/Q3 カリウム チャネル オープナーです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 325457-89-4
Sample solution is provided at 25 µL, 10mM.
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ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects[1][2].
[1]. Wickenden AD, et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. [2]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.
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