Cyproheptadine hydrochloride |
| カタログ番号GC10698 |
シプロヘプタジン塩酸塩は、強力な経口活性 5-HT2A 受容体拮抗薬であり、抗うつ効果と抗セロトニン作動効果があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 969-33-5
Sample solution is provided at 25 µL, 10mM.
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Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1].
Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent. It is used to treat for postgastrectomy-dumping syndrome, pruritic dermatoses, migraine, anorexia, and pituitary-dependent Cushing's syndrome. The major urinary product of cyproheptadine is cyproheptadine glucuronide, a quaternary ammonium compound. Cyproheptadine has some side effects including sedation, drowsiness, hypotension, tachycardia and blood dyscrasias. As a 5-HT2A receptor antagonist, cyproheptadine is found to reverse serotonin-enhanced ADP-induced platelet aggregation in vitro and ex vivo suggesting its antiplatelet and thromboprotective effects. [1, 2]
References:
[1] Levine B, Green-Johnson D, Hogan S, Smialek JE. A cyproheptadine fatality. J Anal Toxicol. 1998 Jan-Feb;22(1):72-4.
[2] Lin OA, Karim ZA, Vemana HP, Espinosa EV, Khasawneh FT. The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9(1):e87026.
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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