A12B4C3 |
| カタログ番号GC50097 |
A12B4C3 は、0.06 μM の IC50 値を持つ強力なヒト ポリヌクレオチド キナーゼ/ホスファターゼ (hPNKP) 阻害剤です。 A12B4C3 は、がん細胞に対する抗増殖活性を持っています。 A12B4C3 は、特定のがん細胞の放射線感受性を高めることもあります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1005129-80-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.
Freschauf et al (2009) Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase. Cancer Res. 69 7739 PMID:19773431 |Freschauf et al (2010) Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. J.Biol.Chem. 285 2351 PMID:19940137 |Schellenberg et al (2011) DNA end processing by polynucleotide kinase/phosphatase. Proc.Natl.Acad.Sci.U.S.A. 108 20855 PMID:22184240
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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