CHMFL-FLT3-122 |
| カタログ番号GC50266 |
強力で選択的なFLT3阻害剤
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1839150-56-9
Sample solution is provided at 25 µL, 10mM.
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Potent and selective FLT3 inhibitor (IC50 = 40 nM). Exhibits >10-fold and 170-fold selectivity for FLT3 over BTK kinase and c-KIT kinase, respectively in vitro. Induces apoptosis by arresting cell cycle in G0/G1 phase in vitro. Suppresses tumor growth in an AML xenograft model. Modestly orally bioavailable.
Li et al (2015) Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leu J.Med.Chem. 58 9625 PMID:26630553
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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