SPT Imidazopyridine 1 |
| カタログ番号GC50328 |
SPT イミダゾピリジン 1 (化合物 1) は、hSPT1 の IC50 が 5.19 nM である、経口活性のある強力な SPT (セリン パルミトイル トランスフェラーゼ) 阻害剤です。
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Cas No.: 1933533-18-6
Sample solution is provided at 25 µL, 10mM.
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Potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM). Dose-dependently inhibits incorporation of 14C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats.
Genin et al (2016) Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase. J.Med.Chem. 59 5904 PMID:27213958
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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