SGC AAK1 1 |
カタログ番号GC50487 |
SGC AAK11は、270nMのIC50および9nMのKiを有する強力かつ選択的なAAK1(AP2関連キナーゼ1)阻害剤である。 SGC AAK1 1 は、BMP2K も強力に阻害します。 SGC AAK1 1 は、AAK1 に関連する Wnt 経路の研究に使用されます。
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Cas No.: 2247894-32-0
Sample solution is provided at 25 µL, 10mM.
Adaptor-associated protein kinase 1 (AAK1) and BMP-2-inducible protein kinase (BMP2K) inhibitor (IC50 values are 233 nM and 1.48 μM for AAK1 and BMP2K, respectively). Inhibits AAK1-dependent phosphorylation of AP2M1. Activates Wnt signaling.
Agajanian et al (2018) AAK1 inhibits WNT signaling by promoting clathrin-mediated endocytosis of LRP6. View pre-publication manuscript.
Average Rating: 5
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