PU 23 |
| カタログ番号GC50595 |
PU 23 は、抗がん剤 6-メルカプトプリンに対する耐性を低下させる活性剤としての非カルボン酸多剤耐性タンパク質 4 (MRP4) 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 817635-93-1
Sample solution is provided at 25 µL, 10mM.
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PU 23 is a Multidrug resistance protein 4 (MRP4/ABCC4) inhibitor. MRP4 is an ATP-binding cassette (ABC) transporter. It is associated with multidrug resistance (MDR), which is becoming a growing challenge to the treatment of cancer and infections[1].
Then compound PU 23 was discovered to improve HEK293/MRP4 cell sensibility to 6-MP dramatically, and low concentration PU 23 (5 μM) achieved the equivalent effect of 50 μM MK571. The accumulation of 6-MP was determined by validated high-performance liquid chromatography methods, and pretreatment of the HEK293/MRP4 cells with 50 μM MK571 or PU 23 resulted in significantly increased accumulation of 6-MP by approximately 1.5 times. This compound was first reported with a novel scaffold compared with previously known MRP4 inhibitors, which is a hopeful molecular tool that can be used for overcoming multidrug resistance research[2].
References:
[1]: Chen Y, Yuan X, et al. Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening. PLoS One. 2018 Oct 15;13(10):e0205175.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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