MS1943 |
| カタログ番号GC39407 |
MS1943 は、IC50 が 120 nM のクラス初の経口生物学的利用可能な EZH2 選択的分解剤です。 MS1943 は、多数のトリプルネガティブ乳がん (TNBC) およびその他のがんおよび非がん細胞株で EZH2 タンパク質レベルを大幅に低下させます。 MS1943 は、複数の TNBC およびその他のがん細胞株の増殖を効果的にブロックします。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2225938-17-8
Sample solution is provided at 25 µL, 10mM.
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MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. MS1943 effectively blocks proliferation of multiple TNBC and other cancer cell lines[1].
[1]. Ma A, et al. Discovery of a first-in-class EZH2 selective degrader.Nat Chem Biol. 2020 Feb;16(2):214-222.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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