MS1943 |
| Catalog No.GC39407 |
MS1943은 IC50이 120nM인 동급 최초의 경구 생체이용 EZH2 선택적 분해제입니다. MS1943은 수많은 삼중 음성 유방암(TNBC) 및 기타 암 및 비암성 세포주에서 EZH2 단백질 수준을 상당히 감소시킵니다. MS1943은 여러 TNBC 및 기타 암 세포주의 증식을 효과적으로 차단합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2225938-17-8
Sample solution is provided at 25 µL, 10mM.
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MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. MS1943 effectively blocks proliferation of multiple TNBC and other cancer cell lines[1].
[1]. Ma A, et al. Discovery of a first-in-class EZH2 selective degrader.Nat Chem Biol. 2020 Feb;16(2):214-222.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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