SR-318 |
| カタログ番号GC39574 |
SR-318 は、p38α、p38β、および p38α/β に対してそれぞれ 5 nM、32 nM、および 6.11 μM の IC50 を持つ強力で選択性の高い p38 MAPK 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2413286-32-3
Sample solution is provided at 25 µL, 10mM.
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SR-318 is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity[1].
[1]. RÖhm S, et al. Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors. J Med Chem. 2019 Dec 12;62(23):10757-10782.
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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