BRD5529 |
| カタログ番号GC39622 |
BRD5529 は、有効な用量依存的 CARD9-TRIM62 タンパク質間相互作用 (PPI) 阻害剤であり、IC50 値は 8.6 μM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1358488-78-4
Sample solution is provided at 25 µL, 10mM.
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BRD5529 is a selective CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction inhibitor with an IC50 of 8.6 μM. BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation and activation of CARD9, and demonstrates cellular activity and selectivity in CARD9-dependent pathways[1].
[1]. Leshchiner ES, et al. Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatorybowel disease. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11392-11397.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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