OTS186935 hydrochloride |
| カタログ番号GC60279 |
OTS186935 塩酸塩は、IC50 が 6.49 nM の強力なタンパク質メチルトランスフェラーゼ SUV39H2 阻害剤です。 OTS186935 塩酸塩は、毒性を検出することなく、マウス異種移植モデルにおいて腫瘍増殖の有意な阻害を示します。 OTS193320 塩酸塩は、がん細胞における γ-H2AX の産生を調節します。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells[1].
OTS186935 hydrochloride inhibits A549 cell growth with an IC50 of 0.67 μM[1].
OTS186935 hydrochloride (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models[1]. Animal Model: Female NOD.CB17-Prkdcscid/J mice (bearing MDA-MB-231 cells )[1]
[1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.
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