SB-633825 |
| カタログ番号GC60335 |
SB-633825 は、TIE2、LOK (STK10)、および BRK の強力な ATP 競合阻害剤であり、IC50 はそれぞれ 3.5 nM、66 nM、150 nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 956613-01-7
Sample solution is provided at 25 µL, 10mM.
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SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1].
SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6)[1]. SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM[1].
[1]. Elkins JM, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34(1):95-103.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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