CIL62 |
| カタログ番号GC60707 |
CIL62 は、カスパーゼ 3/7 に依存しない細胞死誘導因子です。 CIL62 の作用機序は、ネクロスタチン 1 依存性の細胞死です。
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Cas No.: 117593-36-9
Sample solution is provided at 25 µL, 10mM.
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CIL62 is a caspase-3/7-independent cell death inducer. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death[1].
19 µM (5 µg/mL) Necrostatin-1 suppresses CIL62, but CIL62 is not suppressed by the ferroptosis inducers (antioxidants or iron-chelators)[1].
[1]. Kenichi Shimada, et al. Global Survey of Cell Death Mechanisms Reveals Metabolic Regulation of Ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503.
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