Lenalidomide-C4-NH2 hydrochloride (Synonyms: Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride) |
| カタログ番号GC60984 |
レナリドマイド-C4-NH2 塩酸塩は、CRBN タンパク質の動員に使用されるレナリドマイドベースのセレブロン リガンドです。レナリドマイド-C4-NH2 塩酸塩は、リンカーによってタンパク質のリガンドに結合して、PROTAC (化合物 24) を形成できます。それぞれ。
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Sample solution is provided at 25 µL, 10mM.
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Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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