RI(dl)-2 TFA |
| カタログ番号GC61245 |
RI(dl)-2 TFA は、強力かつ選択的な RAD51 媒介 D ループ形成阻害剤で、IC50 は 11.1 μM です。 RI(dl)-2 TFA は RAD51 の ssDNA への結合に影響を与えず、ヒト細胞における相同組換え (HR) 活性を阻害します (IC50 は 3.0 μM)。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC50 of 3.0 μM)[1].
RI(dl)-2 stabilizes nucleoprotein filaments in a nonfunctional state, which are incapable of D-loop activity and simultaneously shielded from related (e.g., RAD52-mediated) pathways that promote single-strand annealing (SSA)[1].RI(dl)-2 does not modulate the affinity of RAD51 to ssDNA or the stability of preformed RAD51-ssDNA complexes when challenged with high concentrations of salt[1].
[1]. Wei Lv, et al. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem. 2016 May 26;59(10):4511-25.
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