A6770 |
| カタログ番号GC46765 |
A6770 は、経口で有効な強力なスフィンゴシン 1-リン酸 (S1P) リアーゼ (S1PL) 阻害剤です。
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Cas No.: 1331754-16-5
Sample solution is provided at 25 µL, 10mM.
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A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1 It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50 = <0.01 µM), an effect that is reduced in the presence of vitamin B6 (EC50 = <100 µM).
1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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