Atorvastatin (calcium salt hydrate) |
| カタログ番号GC46889 |
HMG-CoA還元酵素阻害剤
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 357164-38-6
Sample solution is provided at 25 µL, 10mM.
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Atorvastatin is an inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol synthesis, that has IC50 values of 73, 102, and 0.6 nM for HepG2 cells, human fibroblasts, and rat hepatocytes, respectively.1 Formulations containing atorvastatin have been used in the treatment of hypercholesterolemia and certain dyslipidemias.
1.Shaw, M.K., Newton, R.S., Sliskovic, D.R., et al.Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductaseBiochem. Biophys. Res. Commun.170(2)726-734(1990)
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