Melicopine |
| カタログ番号GC48774 |
抗マラリアおよび抗がん作用を持つアクリドンアルカロイド
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 568-01-4
Sample solution is provided at 25 µL, 10mM.
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Melicopine is an acridone alkaloid that has been found in Z. simulans and has antimalarial and anticancer activities.1 It is active against the chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum with IC50 values of 29.7 and 33.7 µg/ml, respectively. Melicopine is cytotoxic to PC-3M and LNCaP prostate cancer, but not non-cancerous HEK293, cells (IC50s = 47.9, 37.8, and >100 µg/ml, respectively).
1.Wang, C., Wan, J., Mei, Z., et al.Acridone alkaloids with cytotoxic and antimalarial activities from Zanthoxylum simullans HancePharmacogn. Mag.10(37)73-76(2014)
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