Melicopine |
Katalog-Nr.GC48774 |
An acridone alkaloid with antimalarial and anticancer activities
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Cas No.: 568-01-4
Sample solution is provided at 25 µL, 10mM.
Melicopine is an acridone alkaloid that has been found in Z. simulans and has antimalarial and anticancer activities.1 It is active against the chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum with IC50 values of 29.7 and 33.7 µg/ml, respectively. Melicopine is cytotoxic to PC-3M and LNCaP prostate cancer, but not non-cancerous HEK293, cells (IC50s = 47.9, 37.8, and >100 µg/ml, respectively).
1.Wang, C., Wan, J., Mei, Z., et al.Acridone alkaloids with cytotoxic and antimalarial activities from Zanthoxylum simullans HancePharmacogn. Mag.10(37)73-76(2014)
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