Hirudin (54-65; non-sulfated) (trifluoroacetate salt) (Synonyms: H-GDFEEIPEEYLQ-OH, H-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-Gln-OH) |
| カタログ番号GC49091 |
ヒルジンの脱硫酸化ペプチドフラグメント
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Hirudin (54-65; non-sulfated) is a desulfated peptide fragment of hirudin, an anticoagulant produced by H. medicinalis.1 It inhibits fibrin clot formation induced by isolated bovine thrombin with an IC50 value of 3.7 µM.2
1.Niehrs, C., Huttner, W.B., Carvallo, D., et al.Conversion of recombinant hirudin to the natural form by in vitro tyrosine sulfation. Differential substrate specificities of leech and bovine tyrosylprotein sulfotransferasesJ. Biol. Chem.265(16)9314-9318(1990) 2.Payne, M.H., Krstenansky, J.L., Yates, M.T., et al.Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptidesJ. Med. Chem.34(3)1184-1187(1991)
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