Glycerophosphorylethanolamine (sodium salt) (Synonyms: Glycerol 3-phosphorylethanolamine, Glycerylphosphorylethanolamine) |
| カタログ番号GC49273 |
リン脂質エタノールアミンの活性代謝物
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 883288-78-6
Sample solution is provided at 25 µL, 10mM.
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Glycerophosphorylethanolamine is an active phosphodiester metabolite of phosphatidylethanolamine.1,2 It promotes aggregation of amyloid-β (1-40) (Aβ40) in vitro, and levels of glycerophosphorylethanolamine are elevated in postmortem brains isolated from patients with Alzheimer’s disease.
1.Klunk, W.E., Xu, C.J., McClure, R.J., et al.Aggregation of β-amyloid peptide is promoted by membrane phospholipid metabolites elevated in Alzheimer’s disease brainJ. Neurochem.69(1)266-272(1997) 2.Blusztajn, J.K., Lopez Gonzalez-Coviella, I., Logue, M., et al.Levels of phospholipid catabolic intermediates, glycerophosphocholine and glycerophosphoethanolamine, are elevated in brains of Alzheimer’s disease but not of Down’s syndrome patientsBrain Res.536(1-2)240-244(1990)
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