CVT-2738 |
| カタログ番号GC49410 |
ラノラジンの活性代謝物
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5294-61-1
Sample solution is provided at 25 µL, 10mM.
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CVT-2738 is an active metabolite of the antianginal agent ranolazine .1 It is formed from ranolazine by the cytochrome P450 (CYP) isoform CYP3A. CVT-2738 (100 mg/kg) inhibits increases in T-wave height and the RR interval in a mouse model of myocardial ischemia induced by isoprenaline .2
1.Wang, Y., Chen, X., Sun, Z., et al.Development and validation of a sensitive LC-MS/MS assay for simultaneous quantitation of ranolazine and its three metabolites in human plasmaJ. Chromatogr. B889-89010-16(2012) 2.Yao, Z., Gong, S., Guan, T., et al.Synthesis of ranolazine metabolites and their anti-myocardial ischemia activitiesChem. Pharm. Bull. (Tokyo)57(11)1218-1222(2009)
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