Olmutinib |
| カタログ番号GC19270 |
Olmutinib（HM61713; BI-1482694）は、キナーゼドメインの近くにあるシステイン残基に結合する不可逆的なEGFRチロシンキナーゼ阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1353550-13-6
Sample solution is provided at 25 µL, 10mM.
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Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain.
Olmutinib potently inhibits EGFR in HCC827 cells expressing EGFRDEL19 (IC50=9.2 nM) and H1975 cells expressing EGFRL858R/T790M (IC50=10 nM). In contrast, the IC50 of olmutinib against cells expressing EGFRWT is 2225 nM[1].
References:
[1]. Kim ES, et al. Olmutinib: First Global Approval. Drugs.2016 Jul;76(11):1153-7.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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