Taurine (Synonyms: 2-Aminoethanesulfonic acid) |
| カタログ番号GC15184 |
硫黄含有アミノ酸であり、細胞容積の調節に関与する有機オスモライトであるタウリンは、胆汁酸塩の形成のための基質を提供し、細胞内の遊離カルシウム濃度の調節に役割を果たします。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 107-35-7
Sample solution is provided at 25 µL, 10mM.
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Taurine is an organic acid widely distributed in animal tissues.Target: OthersTaurine is a major constituent of bile and can be found in the large intestine and accounts for approximately 0.1% of total human body weight [1]. Taurine is present in high concentration in algae and in the animals including insects and arthropods, but is generally absent or present in traces in the bacterial and plant kingdoms [2]. In cardiac tissue alone, taurine levels of 20 mM or higher may be found. Taurine availability protects against cholestasis induced by monohydroxy bile acids remains confined to guinea pigs [3]. Oral supplementation of taurine results in increased plasma taurine concentrations and is associated with normalization of left ventricular function in both groups of cats. Myocardial concentrations of taurine are directly related to plasma concentrations and low plasma concentrations are found to be associated with myocardial failure in cats, proposing a direct link occurs between decreased taurine concentration in the myocardium and decreased myocardial mechanical function [4].
References:
[1]. Huxtable, R.J., Physiological actions of taurine. Physiol Rev, 1992. 72(1): p. 101-63.
[2]. Huxtable, R.J., Taurine in the central nervous system and the mammalian actions of taurine. Prog Neurobiol, 1989. 32(6): p. 471-533.
[3]. Chesney, R.W., Taurine: its biological role and clinical implications. Adv Pediatr, 1985. 32: p. 1-42.
[4]. Pion, P.D., et al., Myocardial failure in cats associated with low plasma taurine: a reversible cardiomyopathy. Science, 1987. 237(4816): p. 764-8.
| Cas No. | 107-35-7 | SDF | |
| 同義語 | 2-Aminoethanesulfonic acid | ||
| Chemical Name | 2-aminoethanesulfonic acid | ||
| Canonical SMILES | C(CS(=O)(=O)O)N | ||
| Formula | C2H7NO3S | M.Wt | 125.15 |
| 溶解度 | 25 mg/mL in Water(199.76 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 7.9904 mL | 39.9521 mL | 79.9041 mL |
| 5 mM | 1.5981 mL | 7.9904 mL | 15.9808 mL |
| 10 mM | 0.799 mL | 3.9952 mL | 7.9904 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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