AZ-23 (AZ23) |
| カタログ番号GC33090 |
AZ-23 (AZ23) は、2 nM (TrkA)、8 nM (TrkB)、24 nM (FGFR1)、52 nM (Flt3)、55 の IC50 を持つ、ATP 競合的で経口的に生物学的に利用可能な Trk キナーゼ A/B/C 阻害剤です。 nM (Ret)、84 nM (Musk)、99 nM (Lck)、それぞれ。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 915720-21-7
Sample solution is provided at 25 µL, 10mM.
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AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.
AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-δ and TF-1 Cell Lines[1].
AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma[1].
[1]. Thress K, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol Cancer Ther. 2009 Jul; 8(7):1818-27.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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