PROTAC Sirt2-binding moiety 1 (Synonyms: PROTAC Sirt2-binding moiety 1) |
| カタログ番号GC34741 |
PROTAC Sirt2 結合部分 1 は、2.4 μM の IC50 を持つ、選択的で非常に強力な Sirt2 (Sirt2) 阻害剤です。 PROTAC Sirt2 結合部分 1、SirReal1 ベースの部分は、リンカーを介してセレブロン リガンドに結合し、PROTAC を形成して Sirt2 を分解します。
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Cas No.: 1862237-99-7
Sample solution is provided at 25 µL, 10mM.
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PROTAC Sirt2-binding moiety 1 is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. For the development of sirtuin rearranging ligands (SirReals)-based PROTAC[1]. IC50: 2.4 μM (Sirt2)[1].
[1]. Schiedel M, et al. Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem. 2018 Jan 25;61(2):482-491.
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