(±)14(15)-EpETE (Synonyms: (±)14,15 EEQ, (±)14,15epoxy Eicosatetraenoic Acid) |
カタログ番号GC40360 |
EDHF(内皮由来の過分極因子)は、アセチルコリンとブラジキニンに応答して血管内皮細胞から放出される未確認の仲介物であり、NOS-(一酸化窒素)およびCOX由来の(プロスタサイクリン)拡張血管作用とは異なります。
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Cas No.: 131339-24-7
Sample solution is provided at 25 µL, 10mM.
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator. However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined.
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