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N-(n-Butyl)deoxygalactonojirimycin (Synonyms: Lucerastat, NBDGJ)

カタログ番号GC41235

ミグルスタットのガラクトース形態である N-(n-ブチル) デオキシガラクトノジリマイシンは、グルコシルセラミド合成酵素 (GCS) の経口投与可能な阻害剤です。

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N-(n-Butyl)deoxygalactonojirimycin 化学構造

Cas No.: 141206-42-0

サイズ 価格 在庫数 個数
500μg
$63.00
在庫あり
1mg
$110.00
在庫あり
5mg
$271.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

N-(n-Butyl)deoxygalactonojirimycin is an inhibitor of α-D-galactosidase. It has also been shown to prevent glucosylceramide biosynthesis both in vitro and in mouse models of lysosome storage disorders by inhibiting the ceramide-specific glucosyltransferase, UDP-glucose ceramide glucosyltransferase (IC50 = 41.4 µM) without affecting α-glucosidase I and II or β-glucocerebrosidase (IC50s > 1 mM). This compound has been used to sensitize cultured chronic lymphocytic leukemia cells to the chemotherapeutic agents cladribine , chlorambucil , and fludarabine .

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Average Rating: 5 ★★★★★ (Based on Reviews and 2 reference(s) in Google Scholar.)

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