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Hecogenin

カタログ番号GC41491

ヘコゲニンは、多様な生物学的活性を持つ天然ステロイドサポゲニンであり、元々Aから分離されました。

Products are for research use only. Not for human use. We do not sell to patients.

Hecogenin 化学構造

Cas No.: 467-55-0

サイズ 価格 在庫数 個数
100mg
$49.00
在庫あり
250mg
$117.00
在庫あり
1g
$225.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Hecogenin is a natural steroid sapogenin with diverse biological activities that was originally isolated from A. sisalana and has been used in the synthesis of steroids. It has antioxidant, anti-inflammatory, antiproliferative, and neuroprotective properties. Hecogenin (10 μM) decreases superoxide anion formation induced by N-Formyl-Met-Leu-Phe in rat neutrophils by 23.6%. It also inhibits myeloperoxidase (MPO) release from human neutrophils activated by phorbol 12-myristate 13-acetate when used at a concentration of 1 μg/ml. Hecogenin inhibits proliferation of the breast cancer cell lines MDA-MB-231, MDA-MB-468, MCF-10A, MCF-7, T47D, BT474, and SK-BR-3 (IC50s = 28.7-38.2 μM). It decreases the number of glutamate-induced TUNEL-positive primary rat spinal motor neurons by 11% when used at a concentration of 1 μM. In vivo, hecogenin (15 mg/kg) decreases the mucosal lesion area of ethanol-induced gastric ulceration in mice. It also decreases tumor volume in an MDA-MB-231 human breast cancer mouse xenograft model when administered at a dose of 10 mg/kg three times per week.

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Average Rating: 5 ★★★★★ (Based on Reviews and 6 reference(s) in Google Scholar.)

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