(Ala1)-PAR4 (1-6) amide (mouse) (trifluoroacetate salt) (Synonyms: AY-NH2, AYPGKF-NH2, H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2, PAR4-AP, Proteinase-Activated Receptor 4 Activating Peptide) |
| カタログ番号GC41697 |
（Ala1）-PAR4（1-6）アミド（マウス）は、タンパク質酵素活性化受容体4（PAR4）のペプチドアゴニストであり、ラットおよび人間の血小板をin vitroで凝集させます（EC50はそれぞれ15μMおよび60μM）。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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(Ala1)-PAR4 (1-6) amide (mouse) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of rat and human platelets in vitro (EC50s = 15 and 60 μM, respectively). It reduces expression of glycoprotein (GP) Ib, and increases expression of GPIIb/IIIa on the surface of human platelets. (Ala1)-PAR4 (1-6) amide (mouse) induces relaxation of isolated rat aortic rings and contraction of rat gastric longitudinal muscle strips (EC50s = 11 and 110 μM, respectively) as well as inhibits calcium mobilization evoked by capsaicin in rat sensory neurons. In vivo, (Ala1)-PAR4 (1-6) amide (mouse) (1-100 µg) increases latency to paw withdrawal and the nociceptive threshold in response to thermal and mechanical stimuli. (Ala1)-PAR4 (1-6) amide (mouse) (200 µg) also increases paw thickness in a rat paw edema assay.
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