2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (Synonyms: PhIP) |
カタログ番号GC42116 |
2-アミノ-1-メチル-6-フェニルイミダゾ[4,5-b]ピリジンは、肉の調理につながる複素環式アミン (HCA) の最も豊富な生成物です。 DNA損傷および変異原性活動。 2-アミノ-1-メチル-6-フェニルイミダゾ[4,5-b]ピリジンは、組織特異的な発がん性に寄与する可能性のあるエストロゲン活性も持っています。
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Cas No.: 105650-23-5
Sample solution is provided at 25 µL, 10mM.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a food-derived carcinogen that is found in high temperature-cooked fish and meat. In humans, PhIP is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts, which are directly correlated with increased risk of breast, colon, and prostate cancers. Chronic treatment (1 pM/L for 20 cycles) of MCF-10A cells with PhIP induces anchorage-independent cell growth and reduces cellular dependence on growth factors. It increases wild-type H-Ras gene and protein expression, which activates ERK signaling, MMP-2 and MMP-9 protein expression, and NOX1-driven production of reactive oxygen species (ROS) in vitro. In vivo, PhIP pre-treatment of MCF-10A cells increases tumor formation in a murine breast cancer xenograft model. In a CYP1A2 humanized rat model, PhIP induces formation of colon tumors with β-catenin gene mutations that hyperactivate the Wnt signaling pathway, mimicking the phenotype observed in human tumor isolates. In vivo administration of PhIP (400 ppm/week for 52 weeks) also increases the occurrence of atypical hyperplasias and carcinomas in the ventral prostate and seminal vesicles of rats.
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