HA-1004 (hydrochloride) |
| カタログ番号GC43802 |
HA-1004は、タンパク質キナーゼG（PKG）およびPKAの阻害剤です（それぞれのKis値は1.4および2.3μMです）。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 92564-08-4
Sample solution is provided at 25 µL, 10mM.
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HA-1004 is an inhibitor of protein kinase G (PKG) and PKA (Kis = 1.4 and 2.3 µM, respectively). It also inhibits PKC and blocks intracellular calcium mobilization. HA-1004 induces relaxation of isolated rabbit aortic strips precontracted with histamine, serotonin , A23187 , angiotensin II , or prostaglandin F2α , as well as phenylephrine with or without calcium (EC50s = 2.3 and 0.5 µM, respectively). It also inhibits histamine-induced bronchoconstriction in guinea pigs without affecting blood pressure when administered intratracheally at a dose of 0.1 mg per animal.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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