MCH (human, mouse, rat) (trifluoroacetate salt) (Synonyms: Melanin-Concentrating Hormone) |
| カタログ番号GC44137 |
メラニン濃縮ホルモン（MCH）は、内因性の視床下部神経ペプチドホルモンであり、MCH受容体に作用するアゴニストです。
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Sample solution is provided at 25 µL, 10mM.
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Melanin-concentrating hormone (MCH) is an endogenous hypothalamic neuropeptide hormone that is an agonist at MCH receptors. It binds to MCH1 and MCH2 receptors (IC50s = 0.17 and 2.9 nM, respectively, for the human receptors) and stimulates calcium accumulation with EC50 values of 28 and 50 nM, respectively, in an aequorin bioluminescence functional assay. MCH also binds to the rat MCH1 receptor (Ki = 0.16 nM in CHO cells), stimulates calcium accumulation (EC50 = 1.79 nM), and inhibits intracellular cAMP accumulation induced by forskolin . It binds to mouse MCH receptors on melanoma B16 cells (Ki = 33 nM) and dose-dependently activates the mitogen-activated protein kinase (MAPK) signaling pathway. MCH (5 nmol/kg, i.c.v.) increases cumulative food intake in rats.
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